کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10255025 161485 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advances in subunits of PI3K class I in cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی قانونی
پیش نمایش صفحه اول مقاله
Advances in subunits of PI3K class I in cancer
چکیده انگلیسی
Phosphatidylinositol 3-kinases (PI3Ks) include members of a unique and conserved family of intracellular lipid kinases that phosphorylate the 3-hydroxyl group of phosphatidylino-sitols and phosphoinositides. The resultant activation of many intracellular signalling pathways regulates various biological functions such as cell metabolism, survival, growth, proliferation, polarity, and apoptosis. PI3Ks are classified into three types: class I, II, and III. Of them, class I PI3K is most widely studied and plays an important role in the development and progression of tumours. In this review, we describe PI3K family members and their functions, especially the subunits of class I PI3K, their alterations in cancers, as well as PI3K inhibitors and their clinical trial status in cancer-targeted therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 46, Issue 3, April 2014, Pages 169-176
نویسندگان
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