کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10298623 539498 2015 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Baclofen for alcohol dependence: Relationships between baclofen and alcohol dosing and the occurrence of major sedation
ترجمه فارسی عنوان
باکلوفن برای وابستگی به الکل: رابطه بین دوز باکلوفن و الکل و وقوع آرامبخش اصلی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
In total, 1528 patient-months were compiled (70 with an EMS). Univariate analyses demonstrated that the rate of patient-month to EMS increased gradually with AWAC (p<0.001), from 0.9% for AWAC=0 to 9.4% for AWAC >35. There was also a significant gradual risk for EMS associated with DDB (<0.001). Multivariate analysis demonstrated a significant interaction between DDB and AWAC on EMS risk (p=0.047). Each 20 mg/d increase in DDB was associated with an OR of EMS in AWAC >35 of 1.22 (95%CI, 1.08-1.38) versus 1.11 (95%CI, 0.96-1.29) in AWAC=1-35, and 0.95 (95%CI, 0.76-1.19) in AWAC=0. The level of sedation observed in patients using baclofen for alcohol dependence appears to directly depend on the immediate doses of both the baclofen and the alcohol.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 25, Issue 10, October 2015, Pages 1631-1636
نویسندگان
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