کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10298629 | 539498 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Striatal NOS1 has dimorphic expression and activity under stress and nicotine sensitization
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کلمات کلیدی
PBSNOSVTASSCPcaudate-putamen - Caudate-PutamenStriatum - استریاتومphosphate buffer - بافر فسفاتDopamine - دوپامینPhosphate buffered saline - فسفات بافر شورventral tegmental area - ناحیه تگمنتوم شکمیknock-out - ناک اوتNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازNicotine - نیکوتین Nucleus accumbens - هسته accumbensGlu - گلوglutamate - گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To determine the specific role of this enzyme, we analyzed both NOS expression and NO synthesis in the striatum of wild-type and NOS1-knocked out (KO) mice of both sexes in situations of nicotine sensitization and stress. Our results demonstrated differences between the caudate-putamen (CP) and nucleus accumbens (NA). With respect to NOS1 expression, the CP is a dimorphic region (27.5% lower cell density in males), but with a stable production of NO, exclusively due to this isoform. Thus, the nitrergic system of CP may not be involved in stress or nicotine addiction. Conversely, the NA is much more variable and strongly involved in both situations: its NO synthesis displays dimorphic variations at both basal (68.5% reduction in females) and stress levels (65.9% reduction in males), which disappear when nicotine is infused. Thus, the KO animals showed an increase in NO production (21.7%) in the NA, probably by NOS3, in an attempt to compensate the lack of NOS1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 25, Issue 10, October 2015, Pages 1683-1694
Journal: European Neuropsychopharmacology - Volume 25, Issue 10, October 2015, Pages 1683-1694
نویسندگان
David DÃaz, Azucena Rodrigo Murias, Carmelo Antonio Ávila-Zarza, Rodrigo Muñoz-Castañeda, José Aijón, José Ramón Alonso, Eduardo Weruaga,