کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10298668 | 539508 | 2015 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
1H-MRS of the anterior cingulate cortex in childhood and adolescent obsessive-compulsive disorder: A case-control study
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کلمات کلیدی
ANCOVA1H-MRSDSM-IVFWHMInositolNaACY-BOCSCDIINSACCChild depression inventoryGlx - glxObsessive–compulsive disorder - اختلال وسواس فکریCho - برایintelligence quotient - بهره هوشیanalysis of covariance - تجزیه و تحلیل کوواریانسanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceSCARED - ترسیدهDiagnostic and Statistical Manual of Mental Disorders, fourth edition - راهنمای تشخیصی و آماری اختلالات روانی، نسخه چهارمmagnetic resonance spectroscopy - طیف سنجی رزونانس مغناطیسیProton magnetic resonance spectroscopy - طیف سنجی رزونانس مغناطیسی پروتونfull width at half maximum - عرض کامل در نیمی از حداکثرanterior cingulate cortex - قشر سینگولیت قدامی، کورتکس سینگولیت قدامیgrey matter - ماده خاکستریwhite matter - ماده سفیدCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیChildren and adolescents - کودکان و نوجوانانglutamate - گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 1H-MRS of the anterior cingulate cortex in childhood and adolescent obsessive-compulsive disorder: A case-control study 1H-MRS of the anterior cingulate cortex in childhood and adolescent obsessive-compulsive disorder: A case-control study](/preview/png/10298668.png)
چکیده انگلیسی
Abnormal glutamate concentrations in the anterior cingulate cortex (ACC) have been identified in children and adults with obsessive-compulsive disorder (OCD). The purpose of the present study was to measure in vivo 1H-MRS neurometabolite concentrations in the ACC of children and adolescents with OCD, in order to identify metabolite abnormalities compared to healthy controls and to assess their relationship with clinical variables. 3Â T proton-magnetic resonance spectroscopy was used to probe ACC biochemistry in 47 paediatric and adolescent OCD patients (11-18 years old) compared to 31 healthy subjects of similar age, sex and estimated intellectual quotient. There were no significant differences in the concentration of glutamate plus glutamine (Glx) adjusted for CSF between OCD patients and healthy controls [F1,74=0.00; P=0.943], but there were significant differences in the concentration of Glx adjusted for CSF in paediatric and adolescent OCD patients according to duration of illness (less than or more than 24 months) [F2,73=3.95; P=0.024]. In addition, we found significantly lower levels of myo-inositol adjusted for CSF in the ACC [F1,74=5.686; P=0.02] in patients compared with controls. The present findings do not confirm the hypothesis of differences in Glx concentrations in the ACC between children and adolescents with OCD and healthy controls; however, the observation of differences in the Glx concentration in children and adolescent OCD patients depending on the duration of illness is of interest.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 25, Issue 1, January 2015, Pages 60-68
Journal: European Neuropsychopharmacology - Volume 25, Issue 1, January 2015, Pages 60-68
نویسندگان
A.E. Ortiz, A.G. Ortiz, C. Falcon, A. Morer, M.T. Plana, N. Bargalló, L. Lázaro,