کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10298678 | 539508 | 2015 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls
ترجمه فارسی عنوان
نشانگرهای سیگنالینگ گلوتامات در مایع مغزی نخاعی و سرم بیماران مبتلا به اختلال دوقطبی و کنترل سالم
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Glutamate is the major excitatory neurotransmitter in the brain. Aberrations in glutamate signaling have been linked to the pathophysiology of mood disorders. Increased plasma levels of glutamate as well as higher glutamine+glutamate levels in the brain have been demonstrated in patients with bipolar disorder as compared to healthy controls. In this study, we explored the glutamate hypothesis of bipolar disorder by examining peripheral and central levels of amino acids related to glutamate signaling. A total of 215 patients with bipolar disorder and 112 healthy controls from the Swedish St. Göran bipolar project were included in this study. Glutamate, glutamine, glycine, l-serine and d-serine levels were determined in serum and in cerebrospinal fluid using high performance liquid chromatography with fluorescence detection. Serum levels of glutamine, glycine and d-serine were significantly higher whereas l-serine levels were lower in patients with bipolar disorder as compared to controls. No differences between the patient and control group in amino acid levels were observed in cerebrospinal fluid. The observed differences in serum amino acid levels may be interpreted as a systemic aberration in amino acid metabolism that affects several amino acids related to glutamate signaling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 25, Issue 1, January 2015, Pages 133-140
Journal: European Neuropsychopharmacology - Volume 25, Issue 1, January 2015, Pages 133-140
نویسندگان
Erik PÃ¥lsson, Joel Jakobsson, Kristoffer Södersten, Yuko Fujita, Carl Sellgren, Carl-Johan Ekman, Hans Ã
gren, Kenji Hashimoto, Mikael Landén,