کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10298876 | 539668 | 2015 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Progressive recruitment of cortical and striatal regions by inducible postsynaptic density transcripts after increasing doses of antipsychotics with different receptor profiles: Insights for psychosis treatment
ترجمه فارسی عنوان
استخدام پیشرفته مناطق کورتنی و جفتی با استفاده از رونویسی چگالی پستانینپتیک القا شده پس از افزایش دوز آنتی سایکوتیک ها با پروفیل گیرنده های مختلف: بینش برای درمان روانپزشکی
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کلمات کلیدی
ژنهای زودرس، هومر، اسناپین، هالوپریدول، جنون جوانی، اختلال دو قطبی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
We analyzed the differential topography of PSD transcripts by incremental doses of two antipsychotics: haloperidol, the prototypical first generation antipsychotic with prevalent dopamine D2 receptors antagonism, and asenapine, a second generation antipsychotic characterized by multiple receptors occupancy. We investigated the expression of PSD genes involved in synaptic plasticity and previously demonstrated to be modulated by antipsychotics: Homer1a, and its related interacting constitutive genes Homer1b/c and PSD95, as well as Arc, C-fos and Zif-268, also known to be induced by antipsychotics administration. We found that increasing acute doses of haloperidol induced immediate-early genes (IEGs) expression in different striatal areas, which were progressively recruited by incremental doses with a dorsal-to-ventral gradient of expression. Conversely, increasing acute asenapine doses progressively de-recruited IEGs expression in cortical areas and increased striatal genes signal intensity. These effects were mirrored by a progressive reduction in locomotor animal activity by haloperidol, and an opposite increase by asenapine. Thus, we demonstrated for the first time that antipsychotics may progressively recruit PSD-related IEGs expression in cortical and subcortical areas when administered at incremental doses and these effects may reflect a fine-tuned dose-dependent modulation of the PSD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 25, Issue 4, April 2015, Pages 566-582
Journal: European Neuropsychopharmacology - Volume 25, Issue 4, April 2015, Pages 566-582
نویسندگان
Andrea de Bartolomeis, Felice Iasevoli, Federica Marmo, Elisabetta F. Buonaguro, Anna Eramo, Rodolfo Rossi, Livia Avvisati, Gianmarco Latte, Carmine Tomasetti,