کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10299462 | 539726 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genes differentially expressed in CB1 knockout mice: Involvement in the depressive-like phenotype
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
Recent hypotheses to explain the neurobiology of depression underline the role played by stress in mood disorders. The endocannabinoid system is one of the major physiological substrates involved in emotional responses and stress. Thus, mice lacking CB1 receptor exhibit a depressive-like phenotype and an increased vulnerability to deleterious effects of stress. In order to identify possible molecular pathways contributing to this phenotype, we have examined the gene expression profile of mutants at basal conditions and after the exposure to repeated stress. Several genes coding for neurotransmitter receptors, neurotrophic factors, neuropeptides and hormones receptors were differentially expressed in CB1 knockout mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 21, Issue 1, January 2011, Pages 11-22
Journal: European Neuropsychopharmacology - Volume 21, Issue 1, January 2011, Pages 11-22
نویسندگان
Ester Aso, Andrés Ozaita, Miquel-Ãngel Serra, Rafael Maldonado,