کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10299462 539726 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genes differentially expressed in CB1 knockout mice: Involvement in the depressive-like phenotype
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Genes differentially expressed in CB1 knockout mice: Involvement in the depressive-like phenotype
چکیده انگلیسی
Recent hypotheses to explain the neurobiology of depression underline the role played by stress in mood disorders. The endocannabinoid system is one of the major physiological substrates involved in emotional responses and stress. Thus, mice lacking CB1 receptor exhibit a depressive-like phenotype and an increased vulnerability to deleterious effects of stress. In order to identify possible molecular pathways contributing to this phenotype, we have examined the gene expression profile of mutants at basal conditions and after the exposure to repeated stress. Several genes coding for neurotransmitter receptors, neurotrophic factors, neuropeptides and hormones receptors were differentially expressed in CB1 knockout mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 21, Issue 1, January 2011, Pages 11-22
نویسندگان
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