کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10299465 | 539726 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: A focus on urocortin 1
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: A focus on urocortin 1 Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: A focus on urocortin 1](/preview/png/10299465.png)
چکیده انگلیسی
Transcriptome analyses were performed in the anterior raphe area of mutant mice deficient in the serotonin transporter (5-HTT KO) or overexpressing this protein (5-HTT TG), which exhibit opposite changes in anxiety-related behavior. Among genes with altered expression, the gene encoding the neuropeptide urocortin 1 was down-regulated in 5-HTT KO and up-regulated in 5-HTT TG mice. Expression of the gene encoding cocaine-and-amphetamine-related-peptide, which colocalizes with urocortin 1, was also increased in 5-HTT TG mutants. Real-time RT-PCR confirmed these data and immunoautoradiographic labeling showed that parallel changes in neuropeptide levels were confined to the non-preganglionic Edinger-Westphal nucleus. Thus, 5-HTT expression correlates with that of urocortin 1, suggesting that this peptide can be involved in the behavioral changes observed in 5-HTT mutant mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 21, Issue 1, January 2011, Pages 33-44
Journal: European Neuropsychopharmacology - Volume 21, Issue 1, January 2011, Pages 33-44
نویسندگان
Véronique Fabre, Renaud Massart, Adeline Rachalski, Katie Jennings, Andrew Brass, Trevor Sharp, Klaus-Peter Lesch, Laurence Lanfumey, Michel Hamon,