کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10299469 539726 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress
چکیده انگلیسی
Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 21, Issue 1, January 2011, Pages 71-79
نویسندگان
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