کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10300491 | 539941 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative efficacy and safety of long-acting risperidone and risperidone oral tablets
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
A double-blind study of long-acting injectable risperidone and oral risperidone tablets was conducted in 640 patients with schizophrenia. All patients received flexible doses of 1-6 mg of oral risperidone for 8 weeks. Doses were stable during weeks 5-8. At the end of week 8, symptomatically stable patients were randomly assigned to receive long-acting risperidone (active injections, dummy oral) or continued oral risperidone (dummy injections, active oral) for 12 weeks. Significant improvements were demonstrated from baseline to endpoint in Positive and Negative Syndrome Scale (PANSS) total (P<0.001) and factor scores (P<0.05) in both groups. According to a noninferiority analysis, the two treatments showed comparable efficacy in total PANSS scores over the short-term. No unexpected adverse events were recorded. The findings indicate that symptomatically stable patients can be safely switched from oral risperidone to long-acting injectable risperidone without compromising efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 15, Issue 1, January 2005, Pages 111-117
Journal: European Neuropsychopharmacology - Volume 15, Issue 1, January 2005, Pages 111-117
نویسندگان
Pierre Chue, Marielle Eerdekens, Ilse Augustyns, Bernard Lachaux, Peter MolÄan, Lars Eriksson, H. Pretorius, Anthony S. David,