Concurrent attenuated reactivity of alpha-amylase and cortisol is related to disruptive behavior in male adolescents

► Neurobiological parameters were studied in delinquent male adolescents and controls. ► Attenuated alpha-amylase/cortisol reactivity was related to disruptive behavior. ► Both parameters were related to dimensional and categorical measures of behavior. ► Combining the biological parameters improved the explanation of disruptive behavior. ► Concurrent low reactivity of the parameters was related to more disruptive behavior.