کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10303727 | 545613 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative stress in bipolar and schizophrenia patients
ترجمه فارسی عنوان
استرس اکسیداتیو در بیماران دوقطبی و اسکیزوفرنیا
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کلمات کلیدی
اکسیداسیون پروتئین، پراکسیداسیون لیپید، گوانین اکسید شده گلوتاتیون، سوکسوکس دیسموتاز، اختلالات روانی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Oxidative stress has an important place in studies investigating the pathophysiology of psychiatric diseases. In spite of this fact, longitudinal studies are required to clarify the subject. Therefore, in this study, we examined lipid peroxidation, protein oxidation, total oxidized guanine species, superoxide dismutase (SOD) and total glutathione (GSH) levels in blood collected from adult bipolar patients (n=18) during manic and euthymic episodes, schizophrenic patients (n=18) during acute psychotic attack and remission phases and the control group (n=18). There was a significant increase in the level of lipid peroxidation in the bipolar disorder manic episode group (BD-ME) compared to control group. The level of protein oxidation was significantly higher in the schizophrenia acute psychotic attack group (SZ-APA) compared to the control group. The level of total oxidized guanine species was statistically higher in all psychiatric groups compared to the control group. There was no significant difference among the groups with regard to SOD and GSH. Consequently, we believe that lipid peroxidation may be effective in the pathogenesis of bipolar patients; that protein oxidation may be of importance in the pathogenesis of schizophrenia and that total oxidized guanine species may be crucial in the pathogeneses of both psychiatric disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 228, Issue 3, 30 August 2015, Pages 688-694
Journal: Psychiatry Research - Volume 228, Issue 3, 30 August 2015, Pages 688-694
نویسندگان
Ãzgür Korhan Tunçel, Gökhan Sarısoy, BirÅen Bilgici, Ozan Pazvantoglu, Eda Ãetin, Esra Ãnverdi, Bahattin Avcı, Ãmer Böke,