کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10304570 | 545768 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mean cell spacing abnormalities in the neocortex of patients with schizophrenia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mean cell spacing abnormalities in the neocortex of patients with schizophrenia Mean cell spacing abnormalities in the neocortex of patients with schizophrenia](/preview/png/10304570.png)
چکیده انگلیسی
It has been postulated that the prefrontal cortices of schizophrenic patients have significant alterations in their interneuronal (neuropil) space. The present study re-examines this finding based on measurements of mean cell spacing within the cell minicolumn. The population studied consisted of 13 male schizophrenic patients (DSM-IV criteria) and 13 age-matched controls. Photomicrographs of Brodmann's areas 9, 4 (M1), 3b (S1), and 17 (V1) were analyzed with computerized image analysis to measure parameters of minicolumnar morphometry, i.e., columnarity index (CI), minicolumnar width (CW), dispersion of minicolumnar width (VCW), and mean interneuronal distance (MCS). The results indicate alterations in the mean cell spacing of schizophrenic patients according to both the lamina and cortical area examined. The lack of variation in the columnarity index argues in favor of a defect postdating the formation of the cell minicolumn.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 133, Issue 1, 30 January 2005, Pages 1-12
Journal: Psychiatry Research - Volume 133, Issue 1, 30 January 2005, Pages 1-12
نویسندگان
Manuel F. Casanova, Leonie de Zeeuw, Andrew Switala, Pawel Kreczmanski, Hubert Korr, Norbert Ulfig, Helmut Heinsen, Harry W.M. Steinbusch, Christoph Schmitz,