کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10305418 546647 2005 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without posttraumatic stress disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without posttraumatic stress disorder
چکیده انگلیسی
It remains unclear whether smaller hippocampal volume is a consistent feature of chronic posttraumatic stress disorder (PTSD) and whether it accounts for the associated memory deficits observed in this illness. Hippocampal volume, comparison regions and memory performance were examined in Holocaust survivors with PTSD (PTSD+: n = 14; 5 men, 9 women) and without PTSD (PTSD−: n = 13; 6 men, 7 women) and a non-exposed control group of healthy Jewish adults (n = 20; 13 men, 7 women). The subjects had medical examinations, high-resolution magnetic resonance imaging, and memory testing. PTSD+ subjects had poorer memory performance than non-exposed subjects and PTSD− subjects, but they did not differ from either group in right or left hippocampal volume when gender and head size were taken into account. Older age and smaller left hippocampal volume were more strongly associated in the PTSD+ group than in the PTSD− groups. Holocaust survivors had larger superior temporal gyral and lateral temporal lobe volumes bilaterally than non-exposed subjects. Smaller hippocampal volume is not invariably associated with chronic PTSD and does not explain the substantial explicit memory impairment observed in Holocaust survivors with this disorder. Larger temporal lobe volumes may be associated with early traumatization and survival or may reflect some other characteristic of Holocaust survivors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 139, Issue 1, 30 May 2005, Pages 53-64
نویسندگان
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