کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10307429 | 547894 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decreased interleukin-10 serum levels in first-episode drug-naïve schizophrenia: Relationship to psychopathology
ترجمه فارسی عنوان
کاهش سطوح سرمی اینترلوکین-10 در مقابله با اسکیزوفرنی داروی اول اسفنج: ارتباط با روانپزشکی
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کلمات کلیدی
جنون جوانی، سیتوکین ها، اینترلوکین 10، روانپزشکی، شناخت، عملکرد ایمنی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Many lines of findings support the hypothesis of the inflammation-related pathways in the multifactorial pathogenesis of schizophrenia (SZ). Interleukin-10 (IL-10), a potential anti-inflammatory cytokine, was found to be altered in chronic patients with SZ. The aim of this study was to assess the serum levels of IL-10 in first-episode and drug-naïve (FEDN) patients with SZ and its relationships with the psychopathological parameters. Serum IL-10 levels were analyzed using established procedures in 128 FEDN patients with SZ and 62 healthy controls. Schizophrenia symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS) with cognitive factor derived from the five factor model of the PANSS. Compared to the healthy controls, the patients exhibited a significant decrease in IL-10 levels. Serum IL-10 was inversely correlated with the PANSS negative symptom, as well as with the PANSS cognitive factor subscores in patients. Our results suggested that decreased IL-10 may be implicated in the negative symptom and cognitive impairment at the acute stage of schizophrenia episode.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 156, Issue 1, June 2014, Pages 9-14
Journal: Schizophrenia Research - Volume 156, Issue 1, June 2014, Pages 9-14
نویسندگان
Mei Hong Xiu, Gui Gang Yang, Yun Long Tan, Da Chun Chen, Shu Ping Tan, Zhi Ren Wang, Fu De Yang, Olaoluwa Okusaga, Jair C. Soares, Xiang Yang Zhang,