کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10309201 548507 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered amygdala activation in schizophrenia patients during emotion processing
ترجمه فارسی عنوان
فعال شدن آمیگدال تغییر یافته در بیماران اسکیزوفرنی در طی پردازش احساسات
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
Dysfunctional emotion processing in patients suffering from schizophrenia is a prominent clinical feature of great importance for social functioning and subjective well-being. The neurobiological underpinnings are still poorly understood. Here we investigated a large sample of schizophrenia patients and matched healthy controls with an event-related fMRI task during emotion processing using emotional pictures from the International Affective Picture System (IAPS). Schizophrenia patients revealed stronger right amygdala activation during negative and attenuated response during positive affective picture processing compared to healthy controls. Further analysis indicated that medication status influences activation of the ventral anterior cingulate cortex during negative affective stimuli processing. These results might represent a correlate of altered emotional experience in schizophrenia patients who are known to report less positive and more negative affective states in daily life situations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 150, Issue 1, October 2013, Pages 101-106
نویسندگان
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