کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10309297 | 548561 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association between dopamine D3 receptor gene polymorphisms and schizophrenia in an isolate population
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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![عکس صفحه اول مقاله: Association between dopamine D3 receptor gene polymorphisms and schizophrenia in an isolate population Association between dopamine D3 receptor gene polymorphisms and schizophrenia in an isolate population](/preview/png/10309297.png)
چکیده انگلیسی
There are several lines of evidence implicating the dopamine D3 receptor in the pathophysiology of schizophrenia. The Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) has been the most extensively investigated DRD3 variant in connection with the disease but results have been inconclusive. Recent reports indicate that the Ser9Gly polymorphism is in linkage disequilibrium with other markers, but association studies between DRD3 haplotypes and schizophrenia have had mixed results. Genetic heterogeneity may be one of the causes of contradicting results. In order to clarify the role of DRD3 alterations in the aetiology of disease, we have investigated three D3 genetic variants (Ser9Gly, â205-G/A, â7685-G/C) in a sample of patients with schizophrenia or schizoaffective disorder (N=118) and controls (N=162) recruited from a human isolate from Navarra (Northern Spain) of Basque origin. Although no association was found between the Ser9Gly or the â205-A/G polymorphisms and disease, an excess of allele â7685-C was observed in patients (p=0.002 after correction for multiple analyses). Haplotype analysis shows the three markers to be in strong linkage disequilibrium (p<0.0001) and strongly associated with disease (p<1Ã10â5). These results may suggest that these polymorphisms exert a combined or synergistic effect on susceptibility to schizophrenia, or are in linkage with an unknown causative factor. However, further replication in independent samples is required.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 73, Issue 1, 1 February 2005, Pages 49-54
Journal: Schizophrenia Research - Volume 73, Issue 1, 1 February 2005, Pages 49-54
نویسندگان
Susan Staddon, Maria J. Arranz, Dalu Mancama, Fernando Perez-Nievas, Iñaki Arrizabalaga, Richard Anney, Paul Buckland, Amanda Elkin, Sarah Osborne, Janet Munro, Ignacio Mata, Robert W. Kerwin,