Association of collagen with calcium phosphate promoted osteogenic responses of osteoblast-like MG63 cells

▶ Association of COLL with CaP considerably changed physical properties of CaP film. ▶ Osteoblast proliferation was more pronounced on COLL-adsorbed CaP. ▶ Osetoblast differentiation was activated faster and stronger on COLL-associated CaP. ▶ Osteogenic gene expressions were up-regulated by the presence of COLL in CaP film. ▶ Bioactivity of CaP was significantly improved by the association of COLL with CaP.