Femtosecond laser nanostructuring for femtosensitive DNA detection

► We devised a new concept to achieve improved probe-target recognition properties. ► We obtained 3D stand free gold nanofibrous modified DNA electrodes by using MHZ ultrafast laser. ► The developed nanofibrous DNA biosensor was characterized by cyclic voltammetry. ► Our developed gold nanofibrous DNA-modified electrode realizes sensitivity of about 1 fM.