کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10435671 911010 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A unique highly hydrophobic anticancer prodrug self-assembled nanomedicine for cancer therapy
ترجمه فارسی عنوان
داروهای ضد سرطان منحصر به فرد داروهای ضد سرطان ضد سرطان خود را برای درمان سرطان
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
Different from traditional idea, we designed and synthesized a highly hydrophobic reduction-sensitive docetxel prodrug with a disulfide bond inserted into the linker between docetaxel and vitamin E, which could self-assemble in water to form self-assembled nanoparticles without the help of surface active substances. Compared with a docetaxel Tween80-containing formulation, the unique nanomedicine had many advantages, including high drug payload, advanced stability, superior reproducibility, low toxicty, prolonged circulation and increased therapeutic efficacy. The highly reproducible self-assembled nanoparticles prepared by simple nanoprecipitation technology are more attractive and effective nanomedicines, and might be a promising nano-drug delivery system for other anticancer drug.210
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 12, Issue 8, November 2016, Pages 2273-2282
نویسندگان
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