mRNA expression of alpha and beta isoforms of glucocorticoid receptor in peripheral blood mononuclear cells of patients with tuberculosis and its relation with components of the immunoendocrine response

► mRNA hGRα/β ratio is reduced in PBMC of severe tuberculosis patients. ► Severe TB patients present a certain degree of resistance to endogenous GC effects. ► Adrenal steroid and cytokine environment influence the expression of hGR isoforms in TB.