Suppressed monocyte gene expression profile in men versus women with PTSD

► Male subjects with PTSD had an overall pattern of under-expression of genes on monocytes (47 under-expressed versus 4 over-expressed genes). ► There was no transcriptional evidence of chronic inflammation in male PTSD+ subjects. ► In contrast, preliminary data from our pilot sample of female PTSD+ subjects showed a relatively balanced pattern of increased and decreased expression of genes and an increase in activity of pathways related to immune activation. ► The results indicate differential patterns of monocyte gene expression in PTSD, and are suggestive of gender dimorphism in biologic pathways activated in PTSD.