El mecanismo de prolongación de la vida por restricción calórica y la intensificación farmacológica de sus efectos

Evidence is reviewed showing that CR (and perhaps reduced insulin of GH-IGF-1 axis and hormesis) may exhibit anti-aging effects at least partly by a stimulatory action on autophagy, the cell repair mechanism responsible for the house-keeping of cell membranes and organelles including the free radical generators peroxisomes and mitochondria. It is shown that the life-long weekly administration of an anti-lipolytic drug may decrease glucose and insulin levels and stimulate autophagy and intensify the anti-ageing effects of submaximal CR.