Where did I put that? Patients with amnestic mild cognitive impairment demonstrate widespread reductions in activity during the encoding of ecologically relevant object-location associations

► aMCI have difficulty remembering object-location associations vs. healthy elderly. ► fMRI revealed widespread activity reductions not limited to the hippocampus in aMCI. ► Correlation maps suggest aMCI rely on the sensory and motor aspects of objects. ► aMCI rely on encoding mechanisms that differ substantially from healthy elderly.