کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10536857 962617 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Substrate kringle-mediated catalysis by the streptokinase-plasmin activator complex: Critical contribution of kringle-4 revealed by the mutagenesis approaches
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Substrate kringle-mediated catalysis by the streptokinase-plasmin activator complex: Critical contribution of kringle-4 revealed by the mutagenesis approaches
چکیده انگلیسی
► Importance of kringle domains 4 and 5 in substrate plasminogen activation is shown. ► Selective kringle truncations show increase of nearly two orders of magnitude in catalysis. ► Kringle-swapping experiments were done between PG kringles and those of tPA and uPA. ► A subtle conformational trait in the substrate kringles appears to be decisive during catalysis by SK.HPN. ► This study reveals a novel, substrate-driven mechanism of action for streptokinase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics - Volume 1824, Issue 2, February 2012, Pages 326-333
نویسندگان
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