Lysosomes and lysosomal cathepsins in cell death

►Apoptotic pathways and the cathepsins, including granule-mediated cell death. ►Lysosomal cathepsins as effector molecules in the lysosomal pathway of apoptosis. ►Lysosomes and lysosomal cathepsins as amplifiers of apoptotic signaling. ►Antiapoptotic roles of cathepsins. ►Therapeutic perspectives of lysosome targeting.