Blood-pressure-lowering effect of fermented buckwheat sprouts in spontaneously hypertensive rats

► Neo-FBS is a lactic fermentation product of buckwheat sprouts. ► Neo-FBS demonstrated excellent blood-pressure-lowering (BPL) effects in SHRs. ► A single dose of 0.010 mg/kg of neo-FBS caused significant BPL. ► Neo-FBS inhibited ACE activity in vivo and caused arterial relaxation ex vivo. ► It was concluded that both effects were responsible for the excellent BPL effect.