Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry

► The RRLC-QQQ method had a very low limit of detection at ng grade. ► 17 bioactive constituents were simultaneously analyzed in YZT. ► α-allocryptopine were first quantified. ► The analytical time was 9 min and convenient for evaluation of YZT.