Electrochemical study of imipenem's primary metabolite at the mercury electrode

A differential pulse polarographic method for the determination of M1 in the concentration range 10−6 to 10−4 M with a detection limit of 4.5 × 10−7 M was proposed. Also, a method based on controlled adsorptive pre-concentration of M1 on the hanging mercury drop electrode (HMDE) followed by linear sweep voltammetry allows its determination in the concentration range 2 × 10−9 to 4 × 10−8 M with a detection limit of 1.05 × 10−9 M. The proposed methods have been used for the direct determination of M1 in spiked human urine and real human-derived urine with good results and should be appropiate for monitoring purposes.