کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10554091 | 967951 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A rapid and simple procedure for the determination of cannabinoids in hemp food products by gas chromatography-mass spectrometry
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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![عکس صفحه اول مقاله: A rapid and simple procedure for the determination of cannabinoids in hemp food products by gas chromatography-mass spectrometry A rapid and simple procedure for the determination of cannabinoids in hemp food products by gas chromatography-mass spectrometry](/preview/png/10554091.png)
چکیده انگلیسی
A rapid and simple procedure using liquid-liquid extraction and subsequent gas chromatographic mass-spectrometric detection has been developed for determination of Î9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in different hemp foods. After addition of Î8-tetrahydrocannabinol as internal standard, both solid and liquid specimens were extracted with two volumes of 2Â ml of hexane/isopropanol (9:1): Chromatography was performed on a fused silica capillary column and analytes were determined in the selected-ion-monitoring (SIM) mode. The method was validated in the range 1-50Â ng/ml liquid samples or 1-50Â ng/g solid samples for THC and CBN, and 2-50Â ng/ml or ng/g for CBD. Mean recoveries ranged between 78.8 and 90.2% for the different analytes in solid and liquid samples. The quantification limits were 1Â ng/ml or ng/g for THC and CBN and 2Â ng/ml or ng/g CBD. The method was applied to analysis of various hemp foods. THC content in different products varied 50-fold, whereas CBN and CBD were absent in some samples and achieved hundreds of ng/ml or ng/g in others. The concentration ratio (THC + CBN)/CBD was used to differentiate between the phenotypes of cannabis plants in different specimens. Products possibly originating from drug-type cannabis plants were found in the majority of analyzed specimens.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 36, Issue 5, 4 January 2005, Pages 939-946
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 36, Issue 5, 4 January 2005, Pages 939-946
نویسندگان
Manuela Pellegrini, Emilia Marchei, Roberta Pacifici, Simona Pichini,