کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10554102 | 967951 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The rutin/β-cyclodextrin interactions in fully aqueous solution: spectroscopic studies and biological assays
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The rutin/β-cyclodextrin interactions in fully aqueous solution: spectroscopic studies and biological assays The rutin/β-cyclodextrin interactions in fully aqueous solution: spectroscopic studies and biological assays](/preview/png/10554102.png)
چکیده انگلیسی
In the present work the feasibility of β-cyclodextrin complexation was explored, as a tool for improving the aqueous solubility and antioxidant efficacy of rutin. By means of 1H NMR, UV-vis and circular dichroism spectroscopy the single aromatic ring of rutin was found to be inserted into the β-cyclodextrin cavity to form a 1:1 inclusion complex. The effect of β-cyclodextrin on the spectral features of rutin was quantitatively investigated, in fully aqueous medium, by holding the concentration of the guest constant and varying the host concentration. The associated binding constants were estimated to be 142 ± 20 and 153 ± 20 Mâ1, respectively, on the basis of the observed UV-vis absorption and circular dichroism intensities. The antioxidant activity of rutin was also investigated, as affected by molecular encapsulation within β-cyclodextrin (batophenanthroline test; comet assay; lipid peroxidation); the inclusion complex revealed improved antioxidant efficacy that may be in part explained by an increased solubility in the biological moiety.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 36, Issue 5, 4 January 2005, Pages 1019-1027
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 36, Issue 5, 4 January 2005, Pages 1019-1027
نویسندگان
M.L. Calabrò, S. Tommasini, P. Donato, R. Stancanelli, D. Raneri, S. Catania, C. Costa, V. Villari, P. Ficarra, R. Ficarra,