کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10554341 | 967959 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assay validation for three antidepressants in pharmaceutical formulations: Practical approach using capillary gas chromatography
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
An easy and fast capillary gas chromatographic FID method, which was already described by the same authors for the simultaneous determination of fluoxetine, fluvoxamine and clomipramine without derivatization step, is now submitted to a validation procedure in several pharmaceutical formulations. Main aspects of the validation method are examined and discussed, since methods for regulatory submission in most cases must demonstrate: specificity in presence of all potential components, concentration range over which the response is lineal, accuracy, precision, acceptable detection and quantitation limits and stability of the procedure. The pharmaceutical preparations subject of validation were: 'Prozac' (capsules), 'Dumirox' (tablets) and 'Anafranil' (tablets) containing fluoxetine, fluvoxamine and clomipramine, respectively. The results presented in this report show the applied gas chromatographic method is acceptable for the determination of the three antidepressants in the pharmaceutical formulations above mentioned.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 38, Issue 1, 1 June 2005, Pages 52-59
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 38, Issue 1, 1 June 2005, Pages 52-59
نویسندگان
J.J. Berzas Nevado, M.J. Villaseñor Llerena, A.M. Contento Salcedo, E. Aguas Nuevo,