Identification of novel signaling components in genistein-regulated signaling pathways by quantitative phosphoproteomics

► Genistein-regulated phosphoproteins and their regulatory sites were indentified. ► Phosphoproteins were functionally characterized. ► Many phosphosproteins were associated with regulation of cell cycle and apoptosis. ► Signaling cascades mediated by genistein were mapped. ► Novel effector of genistein were newly indentified.