Keywords: RTK ها; CAPRI; Ca2+-promoted RAS inactivator; CRMP-2; collapsin response mediator protein-2; CSRD; cysteine/serine-rich domain; CTD; C-terminal domain; ERK; extracellular signal-regulated kinase; FTI; farnesyltransferase inhibitor; FAK1; focal adhesion kinase 1;
مقالات ISI RTK ها (ترجمه نشده)
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Keywords: RTK ها; BM; bone marrow; CCL2; chemokine (C-C motif) ligand 2; COX2; cyclooxygenase-2; CXCR4; C-X-C chemokine receptor type 4; DC; dendritic cells; ECM; extracellular matrix; FKBP51; FK506 binding protein 51; G-MDSCs; granulocytic MDSCs; GPCRs; G protein coupled
Keywords: RTK ها; Fish; RTKs; Expression; Hypoxic stress; Disease infection
Keywords: RTK ها; α-TOS; α-tocopheryl succinate; BAP1; BRCA1 associated protein-1; BRCA1; breast cancer susceptibility gene 1; CDK4; cyclin-dependent kinase 4; CEA; carcinoembryonic antigen; CSC(s); cancer stem(-like) cell(s); CTGF; connective tissue growth factor (CCN2)
Keywords: RTK ها; ARNT; aryl hydrocarbon nuclear translocator; BCRP; breast cancer resistant protein; CAD; C-terminal activation domain; CAIX; carbonic anhydrase IX; CAV1; caveolin-1; ccRCC; clear cell renal cell carcinoma; CSC; cancer stem cells; DAG; diacylglycerol; DUSP
Keywords: RTK ها; OS; overall survival; MAPK; mitogen-activated protein kinase; RTKs; receptor tyrosine kinases; PI3K; phosphatidylinositide 3-kinases; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; FTIs; farnesyltransferase inhibitors; mTOR;
Keywords: RTK ها; AJ; adherens junction; APC; adenomatous polyposis coli; ARD; armadillo repeat domain; ARVC; arrhythmogenic right ventricular cardiomyopathy; Bsk; Basket; CaM; calmodulin; Cav-1; caveolin-1; CCM; cerebral cavernous malformations; Ccm3; cerebral cavernous m
Keywords: RTK ها; TERT; telomerase reverse transcriptase; RNP; ribonucleoprotein; TR; telomerase RNA; CSCs; cancer stem cells; TEN; telomerase essential N-terminal; TRB; TERT RNA-binding; RT; reverse transcriptase; CTE; C-terminal extension; DAT; dissociates activities of
Keywords: RTK ها; 0EGF; epidermal growth factor; MMP; matrix metalloproteinase; RTKs; receptor tyrosine kinases; PDGF; platelet-derived growth factor; FGF; fibroblast growth factor; VEGF; vascular endothelial growth factor; NGF; nerve growth factor; Neu1; mammalian neurami
Molecularly targeted anti-cancer drugs inhibit the invasion and metastasis of hepatocellular carcinoma by regulating the expression of MMP and TIMP gene families
Keywords: RTK ها; Hepatocellular carcinoma; Sorafenib; Regorafenib; Levnatinib; Invasion; Metastasis; Hepatocellular carcinoma; HCC; Matrix metalloproteinases; MMPs; Tissue inhibitors of MMPs; TIMPs; Extracellular matrix; ECM; Receptor tyrosine kinases; RTKs; Vascular endo
Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis
Keywords: RTK ها; GN; glomerulonephritis; Gas6; growth-arrest-specific protein 6; BUN; blood urine nitrogen; SLE; systemic lupus erythematosus; TAM; (Tyro-3, Axl, and Mer) family; RTKs; receptor tyrosine kinases; B6; C57BL/6J; MTA; mithramycin A; H&E; hematoxylin and eosin
Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential
Keywords: RTK ها; RTKs; Receptor tyrosine kinases; VEGF; vascular endothelial growth factor; VEGFR-2; vascular endothelial growth factor receptor-2; PDGFR-β; platelet-derived growth factor receptor-β; EGFR; epidermal growth factor receptor; ATP; adenosine triphosphate; N
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: RTK ها; Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
Survivin-targeting miR-542-3p overcomes HER3 signaling-induced chemoresistance and enhances the antitumor activity of paclitaxel against HER2-overexpressing breast cancer
Keywords: RTK ها; HER3; Survivin; miRNA; Paclitaxel resistance; Breast cancer; RTKs; Receptor tyrosine kinases; PI-3K; Phosphoinositide 3-kinase; CHX; Cycloheximide; ELISA; Enzyme-linked immunosorbent assay; IHC; Immunohistochemistry; i.p.; Intraperitoneal;
Dissecting the signaling features of the multi-protein complex GPCR/β-arrestin/ERK1/2
Keywords: RTK ها; GPCRs; G protein-coupled receptors; TM; transmembrane; ECLs; extracellular loops; ICLs; intracellular loops; GRKs; G protein-coupled receptor kinases; MAPKs; mitogen activated protein kinases; ERK1/2; extracellular signal-regulated kinases 1 and 2; JNK; c
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: RTK ها; CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
Keywords: RTK ها; ABCB1; ATP-binding cassette sub-family B member 1; AML; acute myeloid leukaemia; AMPK; adenosine monophosphate-activated protein kinase; ATM; Ataxia-telangiectasia mutated; AURKA; aurora kinase A; BER; base excision repair; Bim; B-cell lymphoma 2 interact
Deubiquitylating enzymes as cancer stem cell therapeutics
Keywords: RTK ها; Protein-IPSC; protein-induced pluripotent stem cells; CSCs; cancer stem cells; DUBs; deubiquitylating enzymes; ESCs; embryonic stem cells; PTMs; post-translational modifications; AML; acute myelogenous leukemia; USP/UBP; ubiquitin-specific processing prot
Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents
Keywords: RTK ها; MAPK; RAF inhibitors; Anti-cancer agents; Abl; Abelson murine leukemia viral oncogene; ATP; Adenine triphosphate; Bcl-2; B-cell lymphoma; CNS; Central nervous system; COX-2; Cyclo-oxygenase enzyme-2; CR; Conserved region; CRD; Cysteine-rich domain; DFG; A
Cardiac repair by epicardial EMT: Current targets and a potential role for the primary cilium
Keywords: RTK ها; BBS8; Bardet-Biedl syndrome 8; bFGF; basic fibroblast growth factor; BMP; bone morphogenetic protein; BMSCs; bone marrow-derived hematopoietic stem cells; ECM; extracellular matrix; EGF; epidermal growth factor; EMT; epithelial-to-mesenchymal transition;
Insulin promotes cell migration by regulating PSA-NCAM
Keywords: RTK ها; PSA; polysialic acid; NCAM; neural cell adhesion molecule; ECM; membrane-like extracellular matrix; INS; insulin; WT; wortmannin; PF; PF-562271; p-Akt; phosphorylated Akt; p-FAK; phosphorylated focal adhesion kinase; RTKs; receptor tyrosine kinases; IR-β
Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells
Keywords: RTK ها; BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid tetrakis(acetoxymethyl ester); CRAC; Ca2Â +-release activated Ca2Â + channel; [Ca2Â +]i; cytosolic Ca2Â + concentration; DAG; diacylglycerol; EC; endothelial cell; eNOS; endothelial ni
Dual signaling evoked by oxidized LDLs in vascular cells
Keywords: RTK ها; AAPH; 2,2'-azobis(2-amidinopropane) dihydrochloride; AIF; apoptotic inducing factor; AMVN; 2,4-dimethylvaleronitrile; AP-1; activator protein 1; ATF6; activating transcription factor 6; CDE; clathrin-dependent endocytosis; CCL2; chemokine ligand 2 (or MCP
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: RTK ها; α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions
Keywords: RTK ها; MET; hepatocyte growth factor receptor; PTPRZ1; receptor-type tyrosine-protein phosphatase zeta; ZM; PTPRZ1-MET fusion; HGF; hepatocyte growth factor; NGS; next generation sequencing; RTKs; receptor tyrosine kinases; GBM; glioblastoma multiform; FPKM; f
Functional conservation and divergence of duplicated fibroblast growth factor receptor 1 (fgfr1) genes in blunt snout bream (Megalobrama amblycephala)
Keywords: RTK ها; Fgfr1/fgfr; fibroblast growth factor receptor; Fgf; fibroblast growth factor; MHB; mid-hindbrain boundary; RTKs; receptor tyrosine kinases; HSPG; heparan sulfate proteoglycan; PKC; protein kinase C; PI3K; phosphoinositide 3-kinase; ERKs; extracellular sig
ShcC proteins: Brain aging and beyond
Keywords: RTK ها; ShcC adaptor proteins; Signaling; Aging; Brain ischemia; Brain tumors; Immunity; Aβ; beta-amyloid; AD; Alzheimer's disease; Akt; protein kinase B (PKB); ALK; anaplastic lymphoma kinase (receptor tyrosine kinase); APP; alpha-amyloid precursor protein; ARD
PI3K/Akt signaling in osteosarcoma
Keywords: RTK ها; OS; osteosarcoma; PI3K; phosphatidylinositol 3-kinase; PTEN; phosphatase and tensin homolog; mTOR; mammalian target of rapamycin; RTKs; receptor tyrosine kinases; PDGFR; platelet-derived growth factor receptor; IGF1R; insulin-like growth factor 1 receptor
Photoactivation of Dok1/ERK/PPARγ signaling axis inhibits excessive lipolysis in insulin-resistant adipocytes
Keywords: RTK ها; Akt; protein kinase B; Dex; dexamethasone; Dok1; downstream of tyrosine kinases-1; ERK1/2; extracellular signal-regulated kinase 1 and 2; ap2; fatty acid binding protein 4; IBMX; isobutylmethylxanthine; IRS; insulin receptor substrate; InsR; insulin recep
Research reportAntidepressant-like effects of alarin produced by activation of TrkB receptor signaling pathways in chronic stress mice
Keywords: RTK ها; TrkB; tropomyosin-related kinase B; FST; forced swim test; UCMS; unpredictable chronic mild stress; aCSF; artificial cerebrospinal fluid; RTKs; receptor tyrosine kinases; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinositol 3-kinase; ERK; ex
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents
Keywords: RTK ها; CA-4P; combretastatin A-4 phosphate; VEGFR-2; vascular endothelial growth factor receptor-2; RTKs; receptor tyrosine kinases; 2ME2; 2-methoxyestradiol; PDGFR-β; platelet-derived growth factor receptor β; CAM; chorioallantoic membrane; DDQ; 2,3-dichloro-
NFAT as cancer target: Mission possible?
Keywords: RTK ها; ADP; adenosine di-phosphate; AICD; activation-induced cell death; AKAP79; A-kinase anchor protein 79; Ang-2; angiopoietin-2; AP1; activator protein 1; ARRE-2; antigen receptor response element-2; BMP4; bone morphogenetic protein 4; CABIN1; calcineurin-bin
Inhibition of the Growth of Patient-Derived Pancreatic Cancer Xenografts with the MEK Inhibitor Trametinib Is Augmented by Combined Treatment with the Epidermal Growth Factor Receptor/HER2 Inhibitor Lapatinib
Keywords: RTK ها; EGFR; epidermal growth factor receptor; MRI; magnetic resonance imaging; RTKs; receptor tyrosine kinases; MAPKs; mitogen-activated protein kinases; SMAD4; SMAD family member 4 gene;
Inhibition of EphA4 signaling after ischemia-reperfusion reduces apoptosis of CA1 pyramidal neurons
Keywords: RTK ها; I/R; ischemia-reperfusion; RTKs; receptor tyrosine kinases; CNS; central nervous system; 4VO; four-vessel occlusion; Cdc42; cell division cycle 42; EphA4; EphA4-Fc; Hippocampal neuron; Ischemia-reperfusion; Apoptosis;
Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis—radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib
Keywords: RTK ها; Sunitinib®; VEGFR; RTKs; Iodine-125; Radiolabeling
Research ArticleMet acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver
Keywords: RTK ها; RTKs; receptor tyrosine kinases; HGF; hepatocyte growth factor; 5FU; 5-fluoro-uracile; RU; relative units; ActD; actinomycinD; AU; arbitrary units; RTK signaling in vivo; Cell survival; Embryonic hepatocytes; HGF/Met; Abl; p53 Signaling;
A subset of human gliomas shows over-expression of KIT without its amplification
Keywords: RTK ها; AA; Anaplastic astrocytoma; ACTB; Beta-actin; AO; Anaplastic oligodendroglioma; AOA; Anaplastic oligoastrocytoma; BAC; Bacterial artificial chromosome; BSA; Bovine serum albumin; cDNA; complementary DNA; CISH; Chromogenic in situ hybridization; CNS; Centr
Chemokine receptor CXCR4-mediated transformation of mammary epithelial cells by enhancing multiple RTKs expression and deregulation of the p53/MDM2 axis
Keywords: RTK ها; CXCR4; RTKs; Transformation; P53/MDM2 axis; Signaling network
Identification of novel signaling components in genistein-regulated signaling pathways by quantitative phosphoproteomics
Keywords: RTK ها; SILAC; stable isotope labeling by amino acids in cell culture; PTM; post-translational modification; SCX; strong-cation exchange chromatography; RSD; relative standard deviation; RTKs; receptor tyrosine kinases; GPCRs; G-protein-coupled receptors; BCLAF1;
The HER3/ErbB3 receptor: A promising target in cancer drug therapy
Keywords: RTK ها; HER; human epidermal growth factor receptor; RTKs; receptor tyrosine kinases; EGFR; epidermal growth factor receptor; IGF-1R; insulin-like growth factor type 1 receptor; IGF; insulin-like growth factor; EGF; epidermal growth factor; TGF-α; transforming
Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin
Keywords: RTK ها; DDR1; discoidin domain receptor 1; RTKs; receptor tyrosine kinases; CNS; central nervous system; ISH; in situ hybridization; IHC; immunohistochemistry; WB; western blot; GM; gray matter; WM; white matter; GFAP; glial fibrillary acidic protein; MBP; myelin
Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents1
Keywords: RTK ها; RTKs; receptor tyrosine kinases; PDGFR; platelet-derived growth factor receptor; FGFR; fibroblast growth factor receptor; IGFR; insulin growth factor receptor; VEGFR; vascular endothelial growth factor receptor; EGFR; epidermal growth factor receptor; CAM
Developmental NeuroscienceResearch PaperRor1-Ror2 complexes modulate synapse formation in hippocampal neurons
Keywords: RTK ها; Ror1; Ror2; synaptogenesis; siRNAs; antisense oligonucleotides; E16; embryonic day 16; HEK293; Human embryonic kidney; MEM; minimum essential medium; MUT; mutated; PBS; phosphate buffer saline; RTKs; receptor tyrosine kinases; SCR; scrambled; siRNAs; smal
Ubiquitin in trafficking: The network at work
Keywords: RTK ها; Ubiquitin; Endocytosis; Trafficking; Downmodulation; Signaling; Ubiquitin receptor; RTKs; DUBs
Expression of discoidin domain receptor 1 during mouse brain development follows the progress of myelination
Keywords: RTK ها; carnosine; discoidin domain; myelin; oligodendrocytes; aa; amino acids; APC; anti-adenomatous polyposis coli; BCIP; 5-bromo-4-chloro-3-indolyl phosphate; CA II; carbonic anhydrase II; DDR1; discoidin domain receptor 1; DDR2; discoidin domain receptor 2; E