کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4326958 | 1614103 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
DDR1ISHGFAPMBPOlig2oligodendrocyte transcription factor 2APCRT-qPCRMAGIn situ hybridization - Hybridization در محلRTKs - RTK هاadenomatous polyposis coli - آدنوماتوز پولیپوزیس کولی یا آدنوماتوس پولیپوزیس کولای Schizophrenia - اسکیزوفرنی یا شیزوفرنیOligodendrocyte - الیگودندروسیتImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیHuman cerebral cortex - قشر مغزی انسانGray matter - ماده خاکستریwhite matter - ماده سفیدMyelin - میلینWestern blot - وسترن بلاتGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالMyelin basic protein - پروتئین پایه میلینMyelin-associated glycoprotein - گلیکوپروتئین مرتبط با میلینreceptor tyrosine kinases - گیرنده تیروزین کینازdiscoidin domain receptor 1 - گیرنده دامنه دیسکودین 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin](/preview/png/4326958.png)
چکیده انگلیسی
During development of the mouse brain, the protein kinase discoidin domain receptor 1 (DDR1) is present prenatally in neurons of the proliferative areas, and postnatally, DDR1 expression is no longer detected in neurons, but a spatial-temporal expression pattern in oligodendrocytes that overlaps with the dynamics of the myelination process is detected. Notably, oligodendrocytic DDR1 expression is upregulated in mice during experimentally induced remyelination. Recently, we demonstrated that DDR1 expression is high in human brain and that there is an association between the gene and schizophrenia in a case-control study. However, data regarding expression of DDR1 in the human brain are scarce. Here, we describe the expression pattern of DDR1 in the human adult cerebral cortex. Using several immunohistological techniques and in situ hybridization, we identified DDR1 in the following: a) myelin, b) capillary endothelial cells in the gray as well as white matter, and c) in the soma of some oligodendrocytes and astrocytes in the white matter. The most important overall finding in this study was that DDR1 is present in myelin and is expressed by oligodendrocyte cells. We detected the presence of DDR1 mRNA and protein in myelin and observed that DDR1 co-localized with the classical myelin basic protein (MBP). Moreover, we found a strong positive correlation between expression levels of DDR1 and two myelin-associated genes, myelin-associated glycoprotein (MAG) and oligodendrocyte transcription factor 2 (OLIG2). These observations suggest that DDR1 could be an important constituent of myelin. Because defects in myelination are linked to several mental disorders such as schizophrenia, the function of DDR1 in the process of myelination warrants further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1336, 8 June 2010, Pages 22-29
Journal: Brain Research - Volume 1336, 8 June 2010, Pages 22-29
نویسندگان
Bà rbara Roig, Neus Franco-Pons, Lourdes Martorell, Jordi Tomà s, Wolfgang F. Vogel, Elisabet Vilella,