Differential response to intracellular stress in the skin from osteogenesis imperfecta Brtl mice with lethal and non lethal phenotype: A proteomic approach

► We applied functional proteomics in skin samples from OI murine model Brtl. ► Protein expression changes were found among wild type, mutant lethal and alive mice. ► Class discovery and pathway analyses showed specific profiles for mutants. ► Mainly ER functions and energy balance were affected in mutant mice. ► A skin versus bone comparison was also attempted.