Study on structure and characterization of inclusion complex of gossypol/beta cyclodextrin

The inclusion complex of β-cyclodextrin with gossypol was synthesized by using a convenient method of microwave irradiation. The structure of the complex was determined by 1H NMR, IR spectroscopy, and as well as the elemental analysis; the thermal stability was studied by means of differential thermal analysis (DTA) and thermogravimetric analysis (TGA). The association constant between gossypol and β-cyclodextrin measured via UV spectroscopy was 4462 M−1 at room temperature, following stoichiometry 1:2.