کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10559594 969642 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urinary signature of anabolic steroids and glucocorticoids in humans by LC-MS
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Urinary signature of anabolic steroids and glucocorticoids in humans by LC-MS
چکیده انگلیسی
A metabonomic strategy based on LC-MS was employed to investigate the metabolic profile of urine samples from 20 athletes who had been tested positive for corticoids and anabolic steroids and 29 controls. In this aim, different sample preparations and chromatographic conditions were compared. The acquired LC-MS data of doped athletes and controls were subjected to analysis of variance (ANOVA) and principal component analysis (PCA). Using this approach, molecular signature of human urine was obtained showing that metabonomics could be a complementary tool to discriminate different urinary profiles and to track down metabolic changes in humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 83, Issue 5, 15 February 2011, Pages 1769-1773
نویسندگان
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