کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10574203 | 976519 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reductive nitrosylation of water-soluble iron porphyrins by S-nitroso-N-acetylpenicillamine: Rate constants and EPR characterization
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Reductive nitrosylation of water-soluble iron porphyrins by S-nitroso-N-acetylpenicillamine: Rate constants and EPR characterization Reductive nitrosylation of water-soluble iron porphyrins by S-nitroso-N-acetylpenicillamine: Rate constants and EPR characterization](/preview/png/10574203.png)
چکیده انگلیسی
Reductive nitrosylation of the water-soluble iron derivatives of the cationic FeIII(TMPyP) and anionic FeIII(TPPS) porphyrins [where TMPyPÂ =Â tetra-meso-(4-N-methylpyridiniumyl)porphinate and TPPSÂ =Â tetra-meso-(4-sulfonatophenyl)porphinate] by the nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) was studied using optical absorption spectroscopy and electron paramagnetic resonance. Nitrosylation rates were obtained, the reaction was found to be first order in the SNAP concentration and the stoichiometry of the reaction was one to one. The similarity between the obtained second-order rate constants for both porphyrins, kTMPyPÂ =Â 0.84Â ÃÂ 103Â Mâ1Â sâ1 and kTPPSÂ =Â 0.97Â ÃÂ 103Â Mâ1Â sâ1, suggested that the reaction mechanism is approximately independent of the nature of the porphyrin meso-substituents. A mechanism was proposed involving the hydrolysis of SNAP by an out of plane liganded H2O yielding the sulfenic acid of N-acetylpenicillamine and the transfer of NOâ to FeIII. The EPR (electron paramagnetic resonance) spectra of the SNAP- and gaseous NO-treated porphyrins were obtained and compared. The difference between the spectra of the cationic and anionic porphyrins indicates different local symmetry and Fe-N-O bond angle. SNAP-treatment produced much more resolved hyperfine structures than gaseous NO-treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 100, Issue 11, November 2006, Pages 1722-1729
Journal: Journal of Inorganic Biochemistry - Volume 100, Issue 11, November 2006, Pages 1722-1729
نویسندگان
Fernando S.D.S. Vilhena, Alan W.S. da Silva, Sonia R.W. Louro,