کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10574216 | 976519 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, interaction with double-helical DNA and biological activity of the water soluble complex cis-dichloro-1,2-propylenediamine-N,N,Nâ²,Nâ²-tetraacetato ruthenium (III) (RAP)
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis, interaction with double-helical DNA and biological activity of the water soluble complex cis-dichloro-1,2-propylenediamine-N,N,Nâ²,Nâ²-tetraacetato ruthenium (III) (RAP) Synthesis, interaction with double-helical DNA and biological activity of the water soluble complex cis-dichloro-1,2-propylenediamine-N,N,Nâ²,Nâ²-tetraacetato ruthenium (III) (RAP)](/preview/png/10574216.png)
چکیده انگلیسی
The effects exerted by the new complex cis-dichloro-1,2-propylenediaminetetraacetato ruthenium (III), H[RuCl2(PDTA-H2)] [1, RAP], on DNA and cultured tumor cells (ovarian carcinoma TG cell line) were studied. The comparative study of circular dichroism (CD) spectra obtained from DNA and RAP-DNA system evidences the interaction of the complex with DNA. Compound 1 also interacted with tumor TG cells to slow their proliferation rate. BrdU incorporation was enhanced in cells treated with compound 1, as evidenced by a single-cell electrophoresis method (comet assay), in accordance with RAP-induced DNA damage. DNA migration of compound 1-treated cells was similar to that induced by noxious agents other than cross-linking chemicals. The stability of [RuCl2(PDTA-H2)]-DNA binding is suggested by the high degree of damage that persisted after removal of compound 1 from the culture medium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 100, Issue 11, November 2006, Pages 1834-1841
Journal: Journal of Inorganic Biochemistry - Volume 100, Issue 11, November 2006, Pages 1834-1841
نویسندگان
Rosario A. Vilaplana, Fátima Delmani, Consolación Manteca, José Torreblanca, Javier Moreno, Gregorio GarcÃa-Herdugo, Francisco González-VÃlchez,