Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

A novel series of substituted imidazol-5-ones were designed, synthesized and evaluated for reverse transcriptase inhibition activity using reverse transcriptase (RT) assay kit (Roche, Colorimetric). Docking study was performed to study the binding orientation and affinity of synthesized compounds for RT enzyme.