Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents

A series of cinnamic acyl sulfonamide derivatives have been designed and synthesized, and their biological activities were also evaluated for tubulin inhibitory activity. Compound 10c possessed the most potent biological activity (IC50 = 0.8 μg/mL for B16-F10 and IC50 = 2.4 μg/mL for tubulin). Docking simulation was performed to explore the binding model of compound 10c with tubulin.