کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10582788 981101 2011 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists
چکیده انگلیسی
As part of our efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT6 receptor in order to identify potent and selective ligands for this purpose. Herein we report the identification of a novel series of 3-sulfonylindazole derivatives with acyclic amino side chains as potent and selective 5-HT6 antagonists. The synthesis and detailed SAR of this class of compounds are reported.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 1, 1 January 2011, Pages 650-662
نویسندگان
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