Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 22, Issue 23, 1 December 2014, Pages 6570-6585

Robert M. Rzasa, Michael J. Frohn, Kristin L. Andrews, Samer Chmait, Ning Chen, Jeffrey G. Clarine, Carl Davis, Heather A. Eastwood, Daniel B. Horne, Essa Hu, Adrie D. Jones, Matthew R. Kaller, Roxanne K. Kunz, Silke Miller, Holger Monenschein,