کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10583834 | 981312 | 2013 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: Electrochemical studies on the effects of the quinoidal moiety
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: Electrochemical studies on the effects of the quinoidal moiety Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: Electrochemical studies on the effects of the quinoidal moiety](/preview/png/10583834.png)
چکیده انگلیسی
In our continued search for novel trypanocidal compounds, twenty-six derivatives of naphthoquinones coupled to 1,2,3-triazoles were synthesized. These compounds were evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. Three novel compounds were found to be more potent than the standard drug benznidazole, with IC50/24 h values between 6.8 and 80.8 μM. The electrochemical properties of selected compounds were evaluated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 21, 1 November 2013, Pages 6337-6348
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 21, 1 November 2013, Pages 6337-6348
نویسندگان
Emilay B.T. Diogo, Gleiston G. Dias, Bernardo L. Rodrigues, Tiago T. Guimarães, Wagner O. Valença, Celso A. Camara, Ronaldo N. de Oliveira, Mauro G. da Silva, Vitor F. Ferreira, Yen Galdino de Paiva, Marilia O.F. Goulart, Rubem F.S. Menna-Barreto,