Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2)

A series of novel N-hydroxyfurylacryl-amide-based HDAC inhibitors were designed and synthesized. Amongst these compounds, the compound 10b exhibits selectivity for HDAC6 (IC50 = 0.18 μM) over HDAC1 (IC50 = 4.95 μM) and HDAC4 (IC50 = 10.63 μM). The probable binding mode of compound 10b was analyzed by molecular docking.