Arylazolyl(azinyl)thioacetanilides. Part 10: Design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors

By means of scaffold hopping strategy, imidazopyridine was used as a new bioisostere to replace the five-membered heterocyclic lead structures. This strategy led to the identification of imidazopyridinylthioacetanilide NNRTIs with potency against HIV-1 replication in the low micromolar concentration range.