کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10585353 981366 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid-phase synthesis of 2′-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Solid-phase synthesis of 2′-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines
چکیده انگلیسی
Thirty-one substituted 2′-hydroxychalcones were prepared via an aldol condensation via a solid-phase approach. Chalcones were tested for their growth inhibitory activity in three human tumor cell lines using a SRB assay. To gain further insight on the cellular mechanism of action of this class of compounds, studies of their effect on cell cycle profile as well as on induction of cellular apoptosis were also carried out.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 1, 1 January 2012, Pages 25-33
نویسندگان
, , , , , , , , ,