Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1

The binding conformation of the 7t (blue stick) for AKR1B1 (A) and for AKR1B10 (B), and the difference of binding pocket (C) between AKR1B1 (green solid surface) and AKR1B10 (red wireframe).