Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana

Astrosclerin: kcat = 0.9 × 106 s−1 and kcat/Km = 1.1 × 108 M−1 × s−1, KI(acetazolamide) = 51 nM.